Lexic.us

Definition of Creutzfeldt-Jakob disease

1. Noun. Rare (usually fatal) brain disease (usually in middle age) caused by an unidentified slow virus; characterized by progressive dementia and gradual loss of muscle control.

Definition of Creutzfeldt-Jakob disease

1. Noun. (disease neurology) A rare, progressive, currently fatal disease of the nervous system, characterized by dementia and loss of muscle control. A prion disease, apparently transmissible from animals to humans by eating infected tissue, as well as from tissue interchanges among humans (corneal transplants, blood transfusions). ¹

¹ Source: wiktionary.com

Medical Definition of Creutzfeldt-Jakob disease

1. A very rare form of encephalopathy thought to be caused by a virus (slow-virus), termed a prion. There is little known about the mode of transmission. Human to human transmission has occurred through the use of contaminated brain electrodes and transplantation of infected tissues. The agent can be recovered in the CSF of infected individuals. Standard disinfectants such as formalin, heat, exposure to ultraviolet light or X-rays is ineffective to inactivate the virus. Autoclaving to at least 132 degrees C. Or immersion in 4% sodium hydroxide or 10% sodium hypochlorite solution for 1 hour is recommended for sterilisation. The disease occurs primarily in adults, with peak incidence in the late 50's. Infection results in dementia, myoclonus, ataxia and other neurologic symptoms. The disease progresses rapidly to coma and death after a 3 to 12 month illness. There is no known cure. (27 Sep 1997)

Lexicographical Neighbors of Creutzfeldt-Jakob Disease

Literary usage of Creutzfeldt-Jakob disease

Below you will find example usage of this term as found in modern and/or classical literature:

1. Blood Supply: FDA Oversight and Remaining Issues of Safety edited by Marcia G. Crosse (1999)
""Some researchers believe that Creutzfeldt-Jakob disease is caused by a prion, a small protein particle. Others suggest it may be caused by a virus. ..."

2. Potential Transmission of Spongiform Encephalopathies to Humans: The Food edited by Christopher Shays (1998)
"In humans they are: kuru, Creutzfeldt-Jakob disease, Gerstmann-Straussler- ... Fatal Familial Insomnia, and the new variant Creutzfeldt-Jakob disease first ..."

3. Biosafety in the Laboratory: Prudent Practices for the Handling and Disposal by National Research Council (U. S.) (1989)
"The consequences of infection are grave, however, and there is evidence that Creutzfeldt-Jakob disease has been transmitted to patients by corneal ..."

4. Biosafety in Microbiological and Biomedical Laboratories edited by Jonathan Y. Richmond, Robert W. McKinney (1994)
"However, there is evidence that Creutzfeldt-Jakob disease (CJD) has been transmitted iatrogenically to patients by cornea) transplants, dura mater grafts ..."

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